Inhibition of xanthine oxidase by some Chinese medicinal plants used to treat gout
Identifieur interne : 002F34 ( Main/Exploration ); précédent : 002F33; suivant : 002F35Inhibition of xanthine oxidase by some Chinese medicinal plants used to treat gout
Auteurs : L. D. Kong [République populaire de Chine] ; Y. Cai [République populaire de Chine] ; W. W. Huang [République populaire de Chine] ; Christopher H. K. Cheng [Hong Kong] ; R. X. Tan [République populaire de Chine]Source :
- Journal of Ethnopharmacology [ 0378-8741 ] ; 2000.
English descriptors
Abstract
The enzyme xanthine oxidase catalyses the oxidation of hypoxanthine to xanthine and then to uric acid, which plays a crucial role in gout. A total of 122 traditional Chinese medicinal plants, selected according to the clinical efficacy and prescription frequency for the treatment of gout and other hyperuricemia-related disorders, have been evaluated for the enzyme inhibitory activity. Among the 122 methanol extracts derived from these species, 69 were shown to be inhibitory at 100 μg/ml, with 29 having greater than 50% inhibition. As to the equal amount of water extracts, 40 were disclosed to be active at 100 μg/ml, with 13 possessing more than 50% inhibition. At 50 μg/ml, 58 methanol and 24 water extracts exhibited inhibitory activity, with 15 of the former and two of the latter showing greater than 50% inhibition. The most active was the methanol extract of the twig of Cinnamomum cassia (Lauraceae) (IC50, 18 μg/ml), which was followed immediately by those of the flower of Chrysanthemum indicum (Asteraceae) (IC50, 22 μg/ml) and the leaves of Lycopus europaeus (Lamiatae) (IC50, 26 μg/ml). Among the water extracts, the strongest inhibition of the enzyme was observed with that of the rhizome of Polygonum cuspidatum (Polygonaceae) (IC50, 38 μg/ml). The IC50 value of allopurinol used as a positive control was 1.06 μg/ml. The study demonstrated that the effects for these medicinal plants used for the gout treatment were based, at least in part, on the xanthine oxidase inhibitory action.
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DOI: 10.1016/S0378-8741(00)00305-6
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A total of 122 traditional Chinese medicinal plants, selected according to the clinical efficacy and prescription frequency for the treatment of gout and other hyperuricemia-related disorders, have been evaluated for the enzyme inhibitory activity. Among the 122 methanol extracts derived from these species, 69 were shown to be inhibitory at 100 μg/ml, with 29 having greater than 50% inhibition. As to the equal amount of water extracts, 40 were disclosed to be active at 100 μg/ml, with 13 possessing more than 50% inhibition. At 50 μg/ml, 58 methanol and 24 water extracts exhibited inhibitory activity, with 15 of the former and two of the latter showing greater than 50% inhibition. The most active was the methanol extract of the twig of Cinnamomum cassia (Lauraceae) (IC50, 18 μg/ml), which was followed immediately by those of the flower of Chrysanthemum indicum (Asteraceae) (IC50, 22 μg/ml) and the leaves of Lycopus europaeus (Lamiatae) (IC50, 26 μg/ml). Among the water extracts, the strongest inhibition of the enzyme was observed with that of the rhizome of Polygonum cuspidatum (Polygonaceae) (IC50, 38 μg/ml). The IC50 value of allopurinol used as a positive control was 1.06 μg/ml. The study demonstrated that the effects for these medicinal plants used for the gout treatment were based, at least in part, on the xanthine oxidase inhibitory action.</div></front></TEI><affiliations><list><country><li>Hong Kong</li><li>République populaire de Chine</li></country><settlement><li>Sha Tin</li></settlement><orgName><li>Université chinoise de Hong Kong</li></orgName></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Kong, L D" sort="Kong, L D" uniqKey="Kong L" first="L. D." last="Kong">L. D. Kong</name></noRegion><name sortKey="Cai, Y" sort="Cai, Y" uniqKey="Cai Y" first="Y." last="Cai">Y. Cai</name><name sortKey="Huang, W W" sort="Huang, W W" uniqKey="Huang W" first="W. W." last="Huang">W. W. Huang</name><name sortKey="Tan, R X" sort="Tan, R X" uniqKey="Tan R" first="R. X." last="Tan">R. X. Tan</name><name sortKey="Tan, R X" sort="Tan, R X" uniqKey="Tan R" first="R. X." last="Tan">R. X. Tan</name></country><country name="Hong Kong"><noRegion><name sortKey="Cheng, Christopher H K" sort="Cheng, Christopher H K" uniqKey="Cheng C" first="Christopher H. K." last="Cheng">Christopher H. K. Cheng</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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